Journal
MITOCHONDRION
Volume 7, Issue 5, Pages 289-296Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2007.05.002
Keywords
mitochondria; stem cells; biochemical applications
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Funding
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R03HD046553] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [R21RR021881] Funding Source: NIH RePORTER
- NCRR NIH HHS [R21 RR021881-02, R21 RR021881-03, R21 RR021881-04, R21 RR021881-01] Funding Source: Medline
- NICHD NIH HHS [R03 HD046553-03, R03 HD046553-02S1, R03 HD046553-01A1, R03 HD046553-02] Funding Source: Medline
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The current status of knowledge about mitochondrial properties in mouse, monkey and human embryonic, adult and precursor stem cells is discussed. Topics include mitochondrial localization patterns, oxygen consumption and ATP content in cells as they relate to the maintenance of stem cell properties and subsequent differentiation of stem cells into specific cell types. The significance of the-perinuclear arrangement of mitochondria, which may be a characteristic feature of stem cells, as well as the expression of mitochondrial.DNA regulatory proteins and mutations in the mitochondrial stem cell genome is also discussed. (c) 2007 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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