Journal
TRENDS IN CELL BIOLOGY
Volume 17, Issue 4, Pages 193-201Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2007.02.003
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CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a member of the importin beta superfamily of nuclear transport receptors, recognizing proteins bearing a leucine-rich nuclear export sequence. CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs. Besides its established role in nuclear export, CRM1 is also implicated in various steps during mitosis, widening its functional spectrum within the cell.
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