Journal
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
Volume 3, Issue 2, Pages 209-234Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425255.3.2.209
Keywords
biologically derived therapeutics; cytokines; immunostimulation; toxicity
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The immune system has evolved highly effective mechanisms of surveillance and defense against foreign pathogens, and is also thought to act in surveillance and suppression of cancer. Thus, a predominant. goal of immune system-based therapies is to normalize or enhance the host immune response in the areas of infectious disease and oncology. This review considers general approaches used for therapeutic immunostimulation, alterations in immune response mechanisms that occur with these treatments and the syndromes that commonly arise as a result of these changes. Because nonclinical studies of these therapies are conducted in animal models as the basis for predicting potential human toxicities, this review also considers the value of nonclinical testing to predict human toxicity.
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