gamma delta T lymphocytes - Selectable cells within the innate system?

Lymphocytes expressing gamma delta T cell receptors (TCR) constitute an entire system of functionally specialized subsets that have been implicated in the regulation of immune responses, including responses to pathogens and allergens, and in tissue repair. The gamma delta TCRs share structural features with adaptive receptors and peripheral selection of gamma delta T cells occurs. Nevertheless, their specificities may be primarily directed at self-determinants, and the responses of gamma delta T cells exhibit innate characteristics. Continuous cross talk between gamma delta T cells and myeloid cells is evident in histological studies and in in vitro co-culture experiments, suggesting that gamma delta T cells play a functional role as an integral component of the innate immune system.