Journal
CANCER AND METASTASIS REVIEWS
Volume 26, Issue 1, Pages 5-14Publisher
SPRINGER
DOI: 10.1007/s10555-007-9039-1
Keywords
multidrug resistance; transport; hepatobiliary disposition; pharmacology
Categories
Funding
- NATIONAL CANCER INSTITUTE [R01CA073728, R01CA072937, R01CA085577, U01CA073728, R01CA114574, P30CA006927] Funding Source: NIH RePORTER
- NCI NIH HHS [CA85577, CA73728, CA72937, CA06927, CA114574] Funding Source: Medline
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The MRP family is composed of nine transporters, at least eight of which are lipophilic anion transporters that are capable of conferring resistance to various anticancer agents. Recently, mice with gene disruptions in Mrp2, Mrp3 and Mrp4 have been developed. This review will discuss insights into the physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 afforded by investigations of these new mouse models.
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