Journal
PROSTAGLANDINS & OTHER LIPID MEDIATORS
Volume 82, Issue 1-4, Pages 147-154Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2006.05.026
Keywords
adenomatous polyposis coli; cyclooxygenase-2; colon cancer; Wnt; beta-catenin
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The temporal association between loss of function of the tumor suppressor adenomatous polyposis coli (APC) and overexpression of cyclooxygenase 2 (COX-2) has been demonstrated in vivo and has led to the hypothesis that APC regulates COX-2 expression. This could potentially occur through a variety of mechanisms including the well-characterized ability of APC to negatively regulate Wnt signaling and decrease expression of target genes. However, recent findings suggest that the products of COX-2 elicit effects that occur upstream of the beta-catenin/TCF/LEF pathway. This review will focus on the regulation of COX-2 by APC and the interplay between COX-2 and the Wnt signaling pathway. (c) 2006 Elsevier Inc. All rights reserved.
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