Journal
CANCER GENE THERAPY
Volume 21, Issue 4, Pages 164-170Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cgt.2014.12
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Funding
- Japan Society of Promotion of Sciences
- Ministry of Health, Labor and Welfare of Japan
- Suzuken Memorial foundation
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Recent studies have demonstrated that small double-stranded RNAs (dsRNAs) complementary to the promoter region of target genes enhance the expression of those genes following transfection into cells. Here we show that expression of the matrix metalloproteinase (MMP) inhibitor RECK is activated in the cultured tumor cell lines by transfection with dsRNA complementary to the promoter of the RECK gene, leading to suppression of the expression of MMPs and it inhibited tumor cell invasion. These results support the suggestion that dsRNA complementary to the promoter region of tumor suppressor genes would have potential as a novel antitumor agent.
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