Journal
FRONTIERS IN BIOSCIENCE
Volume 12, Issue -, Pages 1496-1507Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2163
Keywords
HTLV-1 Tax; adult T cell leukemia; anaphase promoting complex; cell cycle; chromosome instability; phosphoinositide 3-kinase; NF-kappa B; review
Categories
Funding
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [R01CA75688, R01CA115884] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA115884, R01CA075688] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [Z01AI001023] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Human T- lymphotropic virus type I ( HTLV- 1) is the etiological agent of adult T- cell leukemia/ lymphoma ( ATL) and HTLV- 1 associated myelopathy/ tropical spastic paraparesis ( HAM/ TSP). HTLV- 1 viral transactivator/ oncoprotein, Tax, activates viral transcription and usurps regulatory mechanisms that are critical for cell growth and division to facilitate viral replication. The effects that Tax exerts on cells include potent NF-.B activation, cell cycle perturbation and cell transformation. How Tax influences ATL development is incompletely understood at present. While Tax- expression is needed at the early stages of cellular transformation, at later times most ATL cells do not express tax; therefore, genetic and epigenetic changes in HTLV- 1- infected cells are believed to play an important role in the etiology of ATL. This review attempts to integrate recent literature on the biological activities of Tax and the properties of HTLV- 1 transformed T- cells and ATL cells, and speculate on what cellular changes may collaborate with Tax to effect cell transformation and ATL development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available