Journal
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
Volume 9, Issue 6, Pages 883-890Publisher
BMC
DOI: 10.1080/10976640701693683
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL062702, R37HL049244] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01HL62702, R37HL49244] Funding Source: Medline
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Cardiac tagging resolution for regional principal strains El and E2 has been a limiting factor for the study of dilated mouse hearts, in which the left ventricle (LV) wall thickness can drop to below 1 mm. Therefore, high resolution tagging was performed at 14.1 T to enable transmural principal strain measurements across the LV wall of normal mouse hearts and average principal strains in thinned LV walls of a transgenic mouse (PKC epsilon TG) that develops dilated LV. A modified DANTE tagging and fast gradient imaging method produced a tagging grid dimension of 0.33 x 0.33 mm and line thickness under 0.1 mm. In normal mice, average El strain in the epicardium was significantly higher than the endocardial El (epi = 0.22 +/- 0.10; endo = 0.13 +/- 0.07, p < 0.05), while magnitude of average endocardial E2 was greater than in the epicardium (endo = -0.12 +/- 0.03, epi = -0.08 +/- 0.03; p < 0.001). El strain averaged over four segments was reduced in dilated hearts compared to controls (PKC epsilon TG = 0.14 +/- 0.02; control = 0.18 +/- 0.02, p < 0.01), with specific reductions in septal (33%) and lateral (31%, p < 0.01) segments. E2 strain was similar between dilated and control hearts at -0.11 +/- 0.01. Thus, improved tagging resolution demonstrates that stretch (El), but not compression strains (E2), are reduced as a result of significant LV wall thinning in a mouse model of dilated cardiomyopathy.
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