Journal
AMYOTROPHIC LATERAL SCLEROSIS
Volume 8, Issue 6, Pages 328-336Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17482960701500718
Keywords
Corpus callosum; hereditary spastic paraparesis; magnetic resonance imaging; voxel-based morphometry
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Three-dimensional magnetic resonance imaging of the brain was analyzed using optimized voxel-based morphometry in 21 patients with pure hereditary spastic paraparesis (pHSP) and 12 patients with complicated HSP (cHSP). PHSP patients showed only small regional grey matter volume reduction, whereas significantly decreased grey matter volumes were localized pericentrally in cHSP. In the white matter, several small areas of regional volume reduction were observed in the pHSP patients, whereas the cHSP group exhibited large robust volume reduction involving the entire corpus callosum, a result that was reproduced by an additional region-based MRI analysis. It could be demonstrated that the topography of cerebral volume changes differed markedly in pHSP or cHSP at group level. Corpus callosum thinning seems to be a general feature of cHSP.
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