4.2 Article

Adult neurogenesis and hippocampal memory function: New cells, more plasticity, new memories?

Journal

NEUROSURGERY CLINICS OF NORTH AMERICA
Volume 18, Issue 1, Pages 105-+

Publisher

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.nec.2006.10.008

Keywords

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Funding

  1. NATIONAL EYE INSTITUTE [T32EY017203] Funding Source: NIH RePORTER
  2. NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH105128] Funding Source: NIH RePORTER
  3. NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS048271, P01NS097206, R01NS047344] Funding Source: NIH RePORTER
  4. NATIONAL INSTITUTE ON AGING [R01AG024984] Funding Source: NIH RePORTER
  5. NEI NIH HHS [T32 EY017203] Funding Source: Medline
  6. NIA NIH HHS [R01 AG024984] Funding Source: Medline
  7. NIMH NIH HHS [R01 MH105128] Funding Source: Medline
  8. NINDS NIH HHS [R01 NS048271, R01 NS047344, P01 NS097206] Funding Source: Medline

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The discovery of active adult neurogenesis in mammals, a process of generating functional neurons from neural stem cells, suggests that the adult brain is more dynamic than once imagined. The coincidence of this phenomenon occurring in the hippocampus, a region critical to the learning process, begs the question of whether adult neurogenesis is involved in memory formation. Here, the authors review rapidly accumulating evidence showing a strong correlation between certain types of memory functions and adult neurogenesis in the hippocampus. Establishment of the potential link between memory formation and adult neurogenesis is instrumental, at a basic science level, to understand the function of neural networks and is essential, at a clinical level, to develop effective therapies for various cognitive dysfunctions.

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