Journal
NEUROSURGERY CLINICS OF NORTH AMERICA
Volume 18, Issue 1, Pages 105-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.nec.2006.10.008
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Funding
- NATIONAL EYE INSTITUTE [T32EY017203] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH105128] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS048271, P01NS097206, R01NS047344] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG024984] Funding Source: NIH RePORTER
- NEI NIH HHS [T32 EY017203] Funding Source: Medline
- NIA NIH HHS [R01 AG024984] Funding Source: Medline
- NIMH NIH HHS [R01 MH105128] Funding Source: Medline
- NINDS NIH HHS [R01 NS048271, R01 NS047344, P01 NS097206] Funding Source: Medline
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The discovery of active adult neurogenesis in mammals, a process of generating functional neurons from neural stem cells, suggests that the adult brain is more dynamic than once imagined. The coincidence of this phenomenon occurring in the hippocampus, a region critical to the learning process, begs the question of whether adult neurogenesis is involved in memory formation. Here, the authors review rapidly accumulating evidence showing a strong correlation between certain types of memory functions and adult neurogenesis in the hippocampus. Establishment of the potential link between memory formation and adult neurogenesis is instrumental, at a basic science level, to understand the function of neural networks and is essential, at a clinical level, to develop effective therapies for various cognitive dysfunctions.
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