Journal
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Volume 23, Issue 8, Pages 1569-1578Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-13-1269
Keywords
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Funding
- Ministry of Education, Taiwan [EMRPD1C0021]
- Ministry of Science and Technology (MOST), Taiwan [102-2325-B-182-014, 102-2320-B-182-029-MY3]
- MOST [102-2325-B-182-010]
- Health Promotion Administration, Ministry of Health and Welfare [PMRPD1B0102]
- Chang Gung Memorial Hospital, Taiwan [CLRPD190013]
- Chang Gung Memorial Hospital [CMRPG1B0551, CMRPG3D0261]
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Background: Oral cavity squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and its incidence is still increasing. Approximately 50% of patients with OSCC die within 5 years after diagnosis, mostly ascribed to the fact that the majority of patients present advanced stages of OSCC at the time of diagnosis. Methods: To discover salivary biomarkers for ameliorating the detection of OSCC, herein, we developed a multiplexed bead-based platform to simultaneously detect auto-antibodies (auto-Abs) in salivary samples. Results: Compared with healthy individuals, the salivary levels of anti-p53, anti-survivin, anti-Hsp60, and anti-RPLP0 were significantly elevated in patients with OSCC. Noteworthily, the elevated levels of anti-p53, anti-survivin, and anti-Hsp60 were already observed in individuals with oral potentially malignant disorder. Moreover, the salivary levels of anti-p53, anti-survivin, anti-Hsp60, anti-RPLP0, and anti-CK8 were significantly elevated in patients with early-stage OSCC compared with those in healthy individuals. Most importantly, the use of a combined panel of salivary anti-p53, anti-survivin, anti-Hsp60, and anti-RPLP0 largely improves the detection of OSCC. Conclusion: Collectively, our results reveal that the salivary auto-Abs are effective OSCC biomarkers and the four-auto-Ab panel provides a novel and practicable approach for OSCC screening. Impact: This study provides the first evidence for the potential clinical application of salivary auto-Abs in OSCC diagnosis. (C) 2014 AACR.
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