Journal
CANCER DETECTION AND PREVENTION
Volume 31, Issue 5, Pages 371-374Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cdp.2007.09.001
Keywords
cervical cancer; MDM2 promoter polymorphism; SNP309; cancer risk factor; primer-introduced restriction analysis (PIRA) PCR; HPV; DNA polymorphism; cervix carcinoma; MDM2 gene; Brazilian population
Categories
Ask authors/readers for more resources
Background: A functional variant in the MDM2 promoter (a T/G substitution, SNP309) was found to be associated with increased expression of MDM2 gene products and at significantly earlier age onset of tumors in both hereditary Li-Fraumeni individuals and sporadic cancer patients. We tested the hypothesis that this functional variant was associated with either risk or early age diagnosis of cervical cancer in a Brazilian population. Methods: A primer-introduced restriction analysis PCR assay was used to genotype the MDM2 SNP309 of 72 cervical carcinoma patients and 100 healthy women. Results: No statistically significant association was observed between SNP309 and cervical cancer. We did not find allele or genotype frequency differences between the group of patients with cancer diagnosis at an early age (younger than 40 years old) and the group of older patients. Conclusions: Our findings suggest that SNP309 MDM2 may not be a risk factor for cervical cancer. (c) 2007 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available