Journal
BIOFACTORS
Volume 30, Issue 1, Pages 13-18Publisher
WILEY
DOI: 10.1002/biof.5520300102
Keywords
decylubiquinone; systolic blood pressure; oxidative stress; LDL-cholesterol; HDL-cholesterol; total cholesterol; triglycerides; malondialdehyde; blood glucose levels; SHRSP
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Decylubiquinone treatment in vitro has demonstrated a potent inhibitor effect on reactive oxidative species production. However, the effect in vivo has not been demonstrated yet. Thus, rats SHRSP male were divided in two groups: treated and controls (n = 6, each). The treated group received 10 mg/Kg(-)/body weight of decylubiquinone diluted in coconut oil by oral gavage during four weeks. Control rats just received the vehicle. Body weight, diuresis, food and water intake, systolic blood pressure, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, blood glucose levels and malondialdehyde were determined. There were a significant (p < 0.05) reduction on systolic blood pressure, plasma malondialdehyde, total cholesterol and LDL-cholesterol in the treated group. Additionally, HDL-cholesterol also increased significantly. However, body weight, diuresis, food and water intake, blood glucose levels and triglycerides did not alter after treatment. Thus, decylubiquinone can be a new antihypertensive, hypolipidemic and antioxidant agent on the prevention and treatment of diseases linked to oxidative stress.
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