Journal
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Volume 22, Issue 4, Pages 597-606Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-12-1248
Keywords
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Funding
- World Cancer Research Fund grant [2006/15]
- Cancer Research UK [C31211/A10095, G0500966/75466]
- UK Medical Research Council [G0600705]
- University of Bristol
- MRC
- UK Department of Health through the NIHR
- National Cancer Research Institute (NCRI)
- Medical Research Council
- MRC [G0600705, G0900871] Funding Source: UKRI
- Medical Research Council [G0600705, G0801462, G0900871] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0509-10242] Funding Source: researchfish
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Background: Ecological and epidemiological studies have identified an inverse association of intensity and duration of sunlight exposure with prostate cancer, which may be explained by a reduction in vitamin D synthesis. Pigmentation traits influence sun exposure and therefore may affect prostate cancer risk. Because observational studies are vulnerable to confounding and measurement error, we used Mendelian randomization to examine the relationship of sun exposure with both prostate cancer risk and the intermediate phenotype, plasma levels of vitamin D. Methods: We created a tanning, a skin color, and a freckling score as combinations of single nucleotide polymorphisms that have been previously associated with these phenotypes. A higher score indicates propensity to burn, have a lighter skin color and freckles. The scores were tested for association with vitamin D levels (25-hydroxyvitamin-D and 1,25-dihydroxyvitamin-D) and prostate-specific antigen detected prostate cancer in 3,123 White British individuals enrolled in the Prostate Testing for cancer and Treatment (ProtecT) study. Results: The freckling score was inversely associated with 25(OH) D levels [change in 25(OH) D per score unit -0.27; 95% CI, -0.52% to -0.01%], and the tanning score was positively associated with prostate cancer risk (OR 1.05; 95% CI, 1.02-1.09), after adjustment for population stratification and potential confounders. Conclusions: Individuals who tend to burn are more likely to spend less time in the sun and consequently have lower plasma vitamin D levels and higher susceptibility to prostate cancer. Impact: The use of pigmentation-related genetic scores is valuable for the assessment of the potential benefits of sun exposure with respect to prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 22(4); 597-606. (C) 2013 AACR.
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