Journal
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
Volume 21, Issue -, Pages 31-34Publisher
ELSEVIER GMBH
DOI: 10.1016/j.jtemb.2007.09.010
Keywords
aluminium; brain distribution; intraperitoneal; oral; rat
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In the present work, accumulation and distribution of aluminium in the rat brain following both intraperitoneal and oral administration were studied. Electrothermal atomic absorption spectrometry was used to determine aluminium concentration in different brain areas (cerebellum, ventral midbrain, cortex, hippocampus, and striatum). Most of the brain areas showed accumulation of aluminium, but a greater and more significant increase was noted in the group receiving aluminium via intraperitoneal administration. Aluminium distribution was also dependent on the administration route. (c) 2007 Elsevier GmbH. All rights reserved.
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