Residential Radon Exposure, Histologic Types, and Lung Cancer Risk. A Case-Control Study in Galicia, Spain

Background: Lung cancer is an important public health problem, and tobacco is the main risk factor followed by residential radon exposure. Recommended exposure levels have been progressively lowered. Galicia, the study area, has high residential radon concentrations. We aim (i) to assess the risk of lung cancer linked to airborne residential radon exposure, (ii) to ascertain whether tobacco modifies radon risk, and (iii) to know whether there is a lung cancer histologic type more susceptible to radon. Methods: A hospital-based case control design was conducted in two Spanish hospitals. Consecutive cases with histologic diagnosis of lung cancer and controls undergoing trivial surgery not tobacco-related were included. Residential radon was measured using standard procedures. Results were obtained using logistic regression. Results: Three hundred and forty-nine cases and 513 controls were included. Radon exposure posed a risk even with a low exposure, with those exposed to 50 to 100 Bq/m(3) having an OR of 1.87 [95% confidence interval (Cl), 1.21-2.88] and of 2.21 (95% Cl, 1.33-3.69) for those exposed to 148 Bq/m(3) or more. Tobacco increased appreciably the risk posed by radon, with an OR of 73 (95% Cl, 19.88-268.14) for heavy smokers exposed to more than 147 Bq/m3. Less frequent histologic types (including large cell carcinomas), followed by small cell lung cancer, had the highest risk associated with radon exposure. Conclusions: The presence of airborne radon even at low concentrations poses a risk of developing lung cancer, with tobacco habit increasing considerably this risk. Impact: Public health initiatives should address the higher risk of lung cancer for smokers exposed to radon. Cancer Epidemiol Biomarkers Prev; 21(6); 951-8. (C) 2012 AACR