Journal
CELLS TISSUES ORGANS
Volume 185, Issue 1-3, Pages 157-161Publisher
KARGER
DOI: 10.1159/000101316
Keywords
microRNAs; gene expression regulation; transforming growth factor-beta 1; epithelial-mesenchymal transition; neoplasms
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Noncoding microRNAs act as posttranscriptional repressors of gene function and are often deregulated in cancers and other diseases. Here we review recent findings on microRNA roles in tumorigenesis and report a microRNA profiling screen in transforming growth factor-beta 1 (TGF-beta)-induced epithelial-mesenchymal transition (EMT) in human keratinocytes, a model of epithelial cell plasticity underlying epidermal injury and skin carcinogenesis. We describe a novel EMT-specific microRNA signature that includes induction of miR-21, a candidate oncogenic microRNA associated with carcinogenesis. By integrating the microRNA screen results with target prediction algorithms and gene expression profiling data, we outline a framework for TGF-beta-directed microRNA: messenger RNA (mRNA) regulatory circuitry and discuss its biological relevance for tumor progression. Copyright (c) 2007 S. Karger AG, Basel.
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