Journal
BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY
Volume 21, Issue 2, Pages 183-193Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bpa.2007.01.003
Keywords
blood transfusion/adverse effects; pulmonary edema; acute lung injury
Categories
Funding
- National Heart Lung and Blood Institute, National Institutes of Health, USA [P50 HL081027]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P50HL081027] Funding Source: NIH RePORTER
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Transfusion-related acute lung injury (TRALI) is defined as new acute lung injury (ALI) that occurs during or within six hours of transfusion, not explained by another ALI risk factor. Transfusion of part of one unit of any blood product can cause TRALI. The mechanism may include factors in unit(s) of blood, such as antibody and biologic response modifiers. In addition, yet to be described factors in a patient's illness may predispose to the condition. The current incidence is estimated to be 1 in 5,000 units. Patients present with acute dyspnea, or froth in the endotracheal tube in intubated patients. Hypertension, hypotension, acute leukopenia have been described. Management is similar to that for ALI and is predominantly supportive. When TRALI is suspected, Blood banks should be notified to quarantine other components from the same donation. No special blood product is required for subsequent transfusion of a patient who has developed TRALI.
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