Journal
PHYSIOLOGY
Volume 22, Issue -, Pages 113-121Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00047.2006
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Funding
- Wellcome Trust Funding Source: Medline
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Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is crucial to maintenance of plasma glucose levels. They fuse with the plasma membrane in a regulated manner to release their contents and are subsequently recaptured either intact or through conventional clathrin-mediated endocytosis. Here, we discuss these mechanisms in beta-cells at the single-vesicle level.
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