Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 17, Issue 3, Pages 91-96Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2007.01.004
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A number of signaling pathways are involved in the regulation of cardiac hypertrophy and remodeling. One that serves as an integrator of upstream inputs, and as a transducer to downstream effectors, is the protein kinase, glycogen synthase kinase-3 beta. In this work we review the role of this putative nodal point in the response of the heart to growth stimuli, both physiologic and pathologic.
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