Journal
GLYCOCONJUGATE JOURNAL
Volume 24, Issue 2-3, Pages 107-123Publisher
SPRINGER
DOI: 10.1007/s10719-006-9023-y
Keywords
carbohydrate; nucleic acid; drug delivery; glycoconjugate; lectin
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Nucleic acids bearing glycans of various structures have been under vigorous investigation in the past decade. The carbohydrate moieties of such complexes can serve as recognition sites for carbohydrate-binding proteins-lectins-and initiate receptor-mediated endocytosis. Therefore, carbohydrates can enhance cell targeting and internalization of nucleic acids that are associated with them and thus improve the bioavailability of nucleic acids as therapeutic agents. This review summarizes nucleic acid glycosylation in nature and approaches for the preparation of both non-covalently associated and covalently-linked carbohydrate-nucleic acid complexes.
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