Journal
SEMINARS IN IMMUNOLOGY
Volume 19, Issue 2, Pages 127-135Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2006.10.001
Keywords
AID; anaerobes; B cell homing; gut homeostasis; intestinal IgA
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Our intestine is colonized by an impressive community of bacteria, that has profound effects on the immune functions. The relationship between gut microbiota and the immune system is one of reciprocity: bacteria have important contribution in nutrient processing and education of the immune system and conversely, the immune system, particularly gut-associated lymphoid tissues (GALT) plays a key role in shaping the repertoire of gut microbiota. In this review we discuss new insights into the role of IgA in the maintenance of immune homeostasis and the reciprocal interactions between gut B cells and intestinal bacteria. (c) 2006 Elsevier Ltd. All rights reserved.
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