Journal
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Volume 19, Issue 10, Pages 2655-2664Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-10-0212
Keywords
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Funding
- Beijing Municipal Science and Technology Commission [D0906008040491]
- Beijing Obstetrics and Gynecology Hospital (Beijing OG Hospital)
- Haidian Maternal and Child Health Care Hospital
- Chaoyang Maternal and Child Health Care Hospital
- Tongzhou Maternal and Child Health Care Hospital
- Dongcheng Maternal and Child Health Care Hospital
- Fengtai Maternal and Child Health Care Hospital
- Huairou Maternal and Child Health Care Hospital
- Yanqing Maternal and Child Health Care Hospital
- Daxing Maternal and Child Health Care Hospital
- Xicheng Maternal and Child Health Care Hospital
- Shijingshan Maternal and Child Health Care Hospital
- Chongwen Maternal and Child Health Care Hospital
- Xuanwu Maternal and Child Health Care Hospital
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Background: Few population-based studies have investigated premalignant and malignant cervical abnormalities in Beijing. Methods: A total of 6,385 randomly selected sexually active women were interviewed and examined. Cervical lesion was diagnosed using cytology and histology. High-risk human papillomavirus (HPV) was detected by the second-generation hybrid capture test and typed by gene chip of DNA from paraffin-embedded tissue. Results: The cervical lesion prevalence diagnosed by histology was 5.8%. High-risk HPV overall prevalence was 9.9%, 50.5% with cervical lesion and 7.4% without cervical lesion. High-risk HPV DNA load increased with increasing degree of lesions. HPV 16 was the most common type (26.5%) among women with cervical lesion, followed by HPV 58 (8.8%), HPV 33 (7.8%), and HPV 56 (5.3%). Women under 50 years of age, married status, pregnancy and delivery status, couple's sexual behavior, contraceptive history, columnar ectopy, and bacterial vaginosis or trichomonas vaginitis history were more risk factors for HPV infection. Factors for cervical lesion were similar, but in comparison with HPV infection, all associations were weakened. Only middle-aged women, husband's sexual partners, oral contraceptives, columnar ectopy, and history of trichomonas vaginitis remained associated with cervical lesion. Conclusion: In Beijing, the prevalence of cervical lesion and high-risk HPV is higher than estimated in previous reports. HPV 16, 58, and 33 were the most prevalent types. This is relevant for work related to cervical cancer vaccination. Impact: The study was conducted to understand the current status and epidemiologic characteristics of women with cervical lesion and HPV infection in Beijing. Cancer Epidemiol Biomarkers Prev; 19(10); 2655-64. (C) 2010 AACR.
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