Journal
DISEASE MARKERS
Volume 23, Issue 1-2, Pages 121-137Publisher
HINDAWI LTD
DOI: 10.1155/2007/394034
Keywords
maternal nutrition; epigenetics; imprinting; methylation; acetylation; DNA; histones; expression; behavior; stress; glucocorticoid; hypothalamic-pituitary-adrenal; glucose; diabetes; metabotomics; reproduction; development; diet; mouse; rat; fox; human; agouti; axin; star; phenotype; genotype; GATACCA
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Funding
- NIA NIH HHS [P01AG20641] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [P01AG020641] Funding Source: NIH RePORTER
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Epigenetics affects health, appearance and behavior and propagates mammalian phenotypes across generations. Nutrients, drugs and behavior can all direct changes in epigenetics. In at least some cases, these directed changes are propagated across generations. This range of influences on epigenetics suggests that epigenetics is highly interactive with the environment. Changes in the environment may regularly change epigenetics and influence our future responses to the environment. The current research challenge is to understand these influences and use them to direct epigenetics toward improved health and longevity.
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