Journal
AAPS JOURNAL
Volume 9, Issue 2, Pages E171-E180Publisher
SPRINGER
DOI: 10.1208/aapsj0902019
Keywords
T-cells; noninvasive imaging; drug delivery; nanoparticles
Categories
Funding
- NIBIB NIH HHS [EB000487] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R56EB000487, R01EB000487] Funding Source: NIH RePORTER
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The T-cell response defines the pathogenesis of many common chronic disease states, including diabetes, rheumatoid arthritis, and transplant rejection. Therefore, a diagnostic strategy that visualizes this response can potentially lead to early therapeutic intervention, avoiding catastrophic organ failure or prolonged sickness. In addition, the means to deliver a drug dose to those cells in situ with the same specificity used to image those cells would provide for a powerful therapeutic alternative for many disease states involving T cells. In this report, we review emerging nanosystems that can be used for simultaneous tracking and drug delivery to those cells. Because of their versatility, these systems-which combine specific receptor targeting with an imaging agent and drug delivery-are suited to both basic science and applications, from developing therapeutic strategies for autoimmune and alloimmune diseases, to noninvasive tracking of pathogenic T-cell migration.
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