Journal
MICROBIOLOGICAL RESEARCH
Volume 162, Issue 4, Pages 322-327Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.micres.2006.01.012
Keywords
Streptomyces; cytotoxic compound; antibacterial activity; quinone; resistoflavine
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In our systematic screening programme for marine actinomycetes, a bioactive Streptomycete was isolated from marine sediment samples of Bay of Bengal, India. The taxonomic studies indicated that the isolate belongs to Streptomyces chibaensis and it was designated as S. chibaensis AUBN(1)/7. The isolate yielded a cytotoxic compound. It was obtained by solvent extraction followed by the chromatographic purification. Based on the spectral. data of the pure compound, it was identified as quinone-related antibiotic, resistoflavine (1). It showed a potent cytotoxic activity against cell lines viz. HMO2 (Gastric adenocarcinoma) and HePG2 (Hepatic carcinoma) in vitro and also exhibited weak antibacterial. activities against Gram-positive and Gram-negative bacteria. (C) 2006 Elsevier GmbH. All rights reserved.
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