Journal
EXPERT OPINION ON DRUG DELIVERY
Volume 4, Issue 1, Pages 27-35Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425247.4.1.27
Keywords
blood-brain barrier; focused ultrasound; HIFU; image-guided therapy; targeted drug delivery; ultrasound
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Funding
- NIBIB NIH HHS [R33EB000705, R01EB003268] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R33EB000705, R01EB003268] Funding Source: NIH RePORTER
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Noninvasive, transient and local image-guided blood-brain barrier disruption can be accomplished using focused ultrasound exposure with intravascular injection of preformed microbubbles. MRI-guided blood-brain barrier disruption has been demonstrated and has been shown to heal in within a few hours after exposure. The delivery of several marker molecules has been demonstrated in different animal models with minimal or no damage to the brain tissue. Most notably, the delivery of antibodies and liposomal doxorubicin has been shown. The method may potentially open a new era in CNS drug delivery and perhaps also aid in molecular imaging and targeting. However, effective clinical devices and methods need to be developed further and the clinical feasibility demonstrated.
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