Journal
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Volume 18, Issue 11, Pages 3110-3117Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-09-0464
Keywords
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Funding
- Prevent Cancer Foundation
- National Cancer Institute [CA63464, CA54281, R01 CA63446, R01 CA77305]
- Komen Foundation Investigator-Initiated [KG080165]
- Women's Circle of Health Study [NCI R01 CA100598, DAMD17-01-1-0334]
- U.S. Army Medical Research Program [DAMD17-96-6071]
- Richard and Susan Smith Family Foundation, Chestnut Hill, MA
- National Institute of Child Health and Human Development [N01-HD-3-3175]
- National Cancer Institute, NIH [RFA-CA-06-503]
- Northern California Cancer Center [U01 CA69417]
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African American women with breast cancer present more commonly with aggressive tumors that do not express the estrogen receptor (ER) and progesterone receptor (PR) compared with European American women. Whether this disparity is the result of inherited factors has not been established. We did an admixture-based genome-wide scan to search for risk alleles for breast cancer that are highly differentiated in frequency between African American and European American women, and may contribute to specific breast cancer phenotypes, such as ER-negative (ER-) disease. African American women with invasive breast cancer (n = 1,484) were pooled from six population-based studies and typed at similar to 1,500 ancestry-informative markers. We investigated global genetic ancestry and did a whole genome admixture scan searching for breast cancer-predisposing loci in association with disease phenotypes. We found a significant difference in ancestry between ER+PR+ and ER-PR- women, with higher European ancestry among ER+PR+ individuals, after controlling for possible confounders (odds ratios for a 0 to 1 change in European ancestry proportion, 2.84; 95% confidence interval, 1.13-7.14; P = 0.026). Women with localized tumors had higher European ancestry than women with non-localized tumors (odds ratios, 2.65; 95% confidence interval, 1.11-6.35; P = 0.029). No genome-wide statistically significant associations were observed between European or African ancestry at any specific locus and breast cancer, or in analyses stratified by ER/PR status, stage, or grade. In summary, in African American women, genetic ancestry is associated with ER/PR status and disease stage. However, we found little evidence that genetic ancestry at any one region contributes significantly to breast cancer risk or hormone receptor status. (Cancer Epidemiol Biomarkers Prev 2009;18(11):3110-7)
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