Journal
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Volume 21, Issue 6, Pages 325-335Publisher
WILEY
DOI: 10.1002/jbt.20197
Keywords
cigarette smoke exposure; neurobehavioral function; dopaminergic neuron system; locomotor activity; guinea pig
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R44HL067735] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [S11ES014156] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R25GM059994, T34GM008037] Funding Source: NIH RePORTER
- NHLBI NIH HHS [T32-HL067735-13] Funding Source: Medline
- NIEHS NIH HHS [S11ES014156] Funding Source: Medline
- NIGMS NIH HHS [2506-GM08037, 2R25GM59994] Funding Source: Medline
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It has been reported that there is an ameliorative effect of cigarette smoking on certain neurological responses and neurodegenerative disorders. The purpose of this study was to examine the neurochemical and neurobehavioral response of cigarette smoke (CS) in the adult male guinea pig brain. Both acute and chronic CS exposure enhanced locomotor behavior and caused a decrease in midbrain dopamine (DA) levels and corresponding increase in 3,4-dihydroxyphenylacetic acid (DOPAC) levels. In addition, CS caused a significant increase in the protein levels of the dopamine 131 and D-2 receptors. CS caused a significant increase in the binding capacity of the D, receptor and a significant decrease in the binding capacity of D2. Furthermore, CS caused a significant increase in the binding capacity of the dopamine transporter (DAT). The mechanism by which cigarette smoke exposure increases locomotor activity remains to be elucidated but may include modulation of dopamine neuron activity that emerges after repeated direct smoke exposure. (c) 2007 Wiley Periodicals, Inc.
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