Journal
MASS SPECTROMETRY REVIEWS
Volume 26, Issue 1, Pages 19-34Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/mas.20104
Keywords
MALDI; DIOS; laser desorption/ionization; mass spectrometry; matrix free
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Matrix assisted laser desorption/ionization (MALDI) is a soft ionization mass spectrometric method that has become a preeminent technique in the analysis of a wide variety of compounds including polymers and proteins. The main drawback of MALDI is that it is difficult to analyze low molecular weight compounds (< 1,000 m/z) because the matrix that allows MALDI to work interferes in this mass range. In recent years there has been considerable interest in developing laser desorption/ ionization (LDI) techniques for the analysis of small molecules. This review examines the approaches to matrix-free LDI mass spectrometry including desorption/ionization on silicon (DIOS), sol-gels, and carbon-based microstructures. For the purposes of this review matrix-free methods are defined as those that do not require matrix to be mixed with the analyte and therefore does not require co-crystallization. The review will also examine mechanisms of ionization and applications of matrix-free LDI-MS. (c) 2006 Wiley Periodicals, Inc.
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