Journal
MICROCIRCULATION
Volume 14, Issue 1, Pages 1-10Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10739680601072099
Keywords
capillary; diabetes; gap junctions; ion channels; pericytes; retina
Categories
Funding
- NEI NIH HHS [EY07003, EY12505] Funding Source: Medline
- NIDDK NIH HHS [DK20572] Funding Source: Medline
- NIMH NIH HHS [MH14279] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY012505] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P60DK020572] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [T32MH014279] Funding Source: NIH RePORTER
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Evidence is accumulating that: pericyte-containing microvessels., Which constitute the largest component of the circulatory system, actively regulate capillary perfusion. Because the retinal vasculature is highly specialized for the local control blood flood, experimental study of its microvessels is proving useful in the quest to elucidate the mechanisms by which local perfusion is regulated. The microcirculation of the retina is also a focus of considerable attention due to its vulnerability to diabetes, wliich is a leading cause of vision loss. Based on the premise that the transmembrane movement of ions plays a critical role in regulating the function of pericytes, investigators are using the patch-clamp technique to study these contractile mural cells. This review highlights recent progress made in understanding how ion channels and transporters mediate responses of the retinal microvasculature to vasoactive signals.
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