Journal
CANCER CYTOPATHOLOGY
Volume 122, Issue 10, Pages 770-778Publisher
WILEY-BLACKWELL
DOI: 10.1002/cncy.21457
Keywords
pancreatic neuroendocrine tumor; fine-needle aspiration; Ki-67; cytology; grading; proliferation index
Funding
- University of California at San Francisco Department of Pathology Endowments for Residents' Teaching and Research
Ask authors/readers for more resources
BACKGROUNDThe natural history of pancreatic neuroendocrine tumors (panNETs) is extremely variable. One of the most controversial problems in diagnosis is the accurate prediction of the clinical behavior of these tumors. PanNETs that behave aggressively with a malignant course may have bland cytologic features, while some tumors with previously described malignant features may behave in a benign or indolent fashion. Various classification schemes have been proposed for grading panNETs. The European Neuroendocrine Tumor Society (ENETS) and 2010 World Health Organization (WHO) classification schemes include counting the mitotic index and/or the Ki-67 proliferation index for grading. The current study was undertaken to determine whether tumors sampled by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) can be accurately graded based on the Ki-67 index when compared to surgical samples. METHODSCorresponding EUS-FNA cytology and surgical tissue specimens were obtained for 22 tumors and stained for hematoxylin and eosin (H&E) and the Ki-67 proliferation marker (MIB-1 antibody). Samples were graded by scoring Ki-67 staining indices in accordance with the 2010 ENETS/WHO criteria. The grading scores assigned to the EUS-FNA cytology samples were compared with the scores assigned to the corresponding histological samples. RESULTSThe majority (86%) of EUS-FNA cytology samples and corresponding surgical tissue specimens demonstrated concordant grading based on Ki-67 indices. CONCLUSIONSThese results indicate that EUS-FNA cytology samples can be accurately graded based on the WHO Ki-67 labeling scheme. Thus, Ki-67 scoring in EUS-FNA cytology samples is an alternative approach for establishing the grade of panNETs. Accurate grading of panNETs is critical for predicting tumor biology, patient prognosis, and making informed decisions regarding patient management and treatment. Cancer (Cancer Cytopathol) 2014;122:770-778. (c) 2014 American Cancer Society. The precise and accurate grading of pancreatic neuroendocrine tumors is critical for predicting biologic behavior patient prognosis, and making informed decisions regarding patient management and treatment. Pancreatic neuroendocrine tumors can be accurately graded by analyzing the Ki-67 proliferation indices in fine-needle aspiration specimens.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available