Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 29, Issue 3, Pages 261-274Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-007-0080-5
Keywords
host-pathogen interaction; innate immunity; pyrin domain; immune modulation; inflammasome inhibitors
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The innate immune system is a dynamic and complex network for recognizing and responding to cellular insult or tissue damage after infection or injury. The primary effector mechanism of innate immunity is the generation of acute and chronic inflammatory responses through regulation of the processing and activation of proinflammatory caspases, particularly caspase 1, and cytokines, most notably IL-1 beta and IL-18. Inflammasomes, cytosolic multi-protein complexes that function as molecular scaffolds for caspase activation, have recently emerged as the pivotal mechanism by which host innate immune and inflammatory responses are regulated. In this review, we investigate the mechanisms by which inflammasomes are modulated, both by endogenous host systems and by microbial pathogens.
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