Journal
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
Volume 30, Issue 5-6, Pages 287-307Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cimid.2007.05.008
Keywords
Hendra virus; Nipah virus; paramyxoviruses
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Funding
- FIC NIH HHS [R01-TW05869] Funding Source: Medline
- NIAID NIH HHS [U01-AI056423-01] Funding Source: Medline
- FOGARTY INTERNATIONAL CENTER [R01TW005869] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI056423] Funding Source: NIH RePORTER
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Following the discovery of two new paramyxoviruses in the 1990s, much effort has been placed on rapidly finding the reservoir hosts, characterising the genomes, identifying the viral receptors and formulating potential vaccines and therapeutic options for these viruses, Hendra and Nipah viruses caused zoonotic disease on a scale not seen before with other paramyxoviruses. Nipah virus particularly caused high morbidity and mortality in humans and high morbidity in pig populations in the first outbreak in Malaysia. Both viruses continue to pose a threat with sporadic outbreaks continuing into the 21st century. Experimental and surveillance studies identified that pteropus bats are the reservoir hosts. Research continues in an attempt to understand events that precipitated spillover of these viruses. Discovered on the cusp of the molecular technology revolution, much progress has been made in understanding these new viruses. This review endeavours to capture the depth and breadth of these recent advances. (C) 2007 Elsevier Ltd. All rights reserved.
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