Journal
NEUROPSYCHOLOGY REVIEW
Volume 17, Issue 3, Pages 275-297Publisher
SPRINGER
DOI: 10.1007/s11065-007-9031-0
Keywords
central nervous system; methamphetamine; abuse; dependence; neuropsychological assessment; cognition
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [P30MH062512] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [P01DA012065] Funding Source: NIH RePORTER
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This review provides a critical analysis of the central nervous system effects of acute and chronic methamphetamine (MA) use, which is linked to numerous adverse psychosocial, neuropsychiatric, and medical problems. A meta-analysis of the neuropsychological effects of MA abuse/dependence revealed broadly medium effect sizes, showing deficits in episodic memory, executive functions, information processing speed, motor skills, language, and vistioconstructional abilities. The neuropsychological deficits associated with MA abuse/dependence are interpreted with regard to their possible neural mechanisms, most notably MA-associated frontostriatal neurotoxicity. In addition, potential explanatory factors are considered, including demographics (e.g., gender), MA use characteristics (e.g., duration of abstinence), and the influence of common psychiatric (e.g., other substancerelated disorders) and neuromedical (e.g., HIV infection) comorbidities. Finally, these findings are discussed with respect to their potential contribution to the clinical management of persons with MA abuse/dependence.
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