Journal
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
Volume 12, Issue 1, Pages 3-13Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10911-007-9033-9
Keywords
early involution; NF-kappa B; PI(3)K; Stat3; TGF beta
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Mammary gland involution occurs in two distinct phases: an early, reversible phase, involving extensive apoptosis of the secretory alveolar epithelium without major changes in gland architecture, and a later, irreversible phase, involving remodelling of the gland to its pre-pregnancy state. Multiple signalling pathways are known to be important during early involution, however the precise triggers remain elusive. This review summarizes the roles of a number of key pathways (NF-kappa B, PI(3)K, Stat3, and TGF beta) in the first phase of involution.
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