Journal
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Volume 71, Issue 5, Pages 1183-1190Publisher
SPRINGER
DOI: 10.1007/s00280-013-2112-2
Keywords
Bendamustine; Erlotinib; Lymphopenia; Triple negative breast cancer; Metastatic breast cancer
Categories
Funding
- National Comprehensive Cancer Network (NCCN)
- Cephalon, Inc.
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Triple negative breast cancers (TNBC) frequently have high epidermal growth factor receptor (EGFR) expression and are sensitive to DNA-damaging agents. Improved therapies are needed for this aggressive malignancy. We performed a phase I trial of bendamustine and erlotinib, an EGFR tyrosine kinase inhibitor, in patients with metastatic TNBC, ECOG performance status a parts per thousand currency sign2, and a parts per thousand currency sign1 prior chemotherapy for metastatic disease. Each 28-day cycle included intravenous bendamustine on days 1, 2 and oral erlotinib on days 5-21 with dose escalation according to a 3 + 3 phase I study design. Dose-limiting toxicity (DLT) was determined by toxicities related to study therapy observed during cycle 1. Eleven patients were treated, 5 on dose level 1 and 6 on dose level 2. One patient had DLT on dose level 2. However, cumulative toxicities were observed, including grade 3/4 lymphopenia in 91 % (95 % CI 0.59-0.998) with progressively decreased CD4 counts and grade a parts per thousand yen3 infections in 36 % (95 % CI 0.11-0.69) of patients. Combination therapy with bendamustine and erlotinib causes excessive toxicity with severe, prolonged lymphopenia, depressed CD4 counts, and opportunistic infections and should not be pursued further. Future trials of bendamustine combinations in TNBC patients should account for potential cumulative lymphocyte toxicity necessitating patient monitoring during and after treatment.
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