Journal
ANNUAL REVIEW OF IMMUNOLOGY
Volume 25, Issue -, Pages 681-695Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.immunol.24.021605.090600
Keywords
sensory cells; immunological synapse; activation; thymic selection
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In light of recent data showing that both helper and cytotoxic T cells can detect even a single molecule of an agonist peptide-MHC, alpha beta T cells are clearly a type of sensory cell, comparable to any in the nervous system. In addition, endogenous (self) peptides bound to MHCs are not just important for thymic selection, but also play in integral role in T cell activation in the response to foreign antigens. With the multitude of specificities available to most T cells, they can thus be considered as a sensory organ, trained on self-peptide-MHCs and primed to detect nonself.
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