Journal
JOURNAL OF LIPOSOME RESEARCH
Volume 17, Issue 3-4, Pages 183-189Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/08982100701530290
Keywords
cisplatin; carboplatin; oxaliplatin; lipid formulation; nanocapsules; improved cytotoxicity; formulation technology; anti-cancer drugs
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Platinum-based anti-cancer agents have been used for many years to treat many different types of cancer. However, the efflicacy of these drugs is limited by serious side effects. One of the strategies to reduce the side effects is encapsulation of the drug in a lipid formulation. Recently, we discovered a novel method for the efficient encapsulation of cisplatin in a lipid. formulation. The method is unique in that it does not generate conventional liposomes but nanocapsules: small aggregates of solid cisplatin covered by a lipid bilayer. Also carboplatin, a cisplatin-derived anti-cancer drug with different chemical properties, can be efficiently encapsulated by a similar method. The encapsulation in nanocapsules dramatically improves the in vitro cytotoxicity of the platinum drugs. Our results hold the promise that the nanocapsule technology could prove successful in the efficient encapsulation of many other (platinum-based) drugs, and thereby improve their therapeutic index and profile in vivo.
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