Journal
EXPERIMENTAL LUNG RESEARCH
Volume 33, Issue 7, Pages 375-384Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/01902140701634843
Keywords
age; acute lung injury; IL-1 beta; LPS; TNF-alpha
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In aged humans and animals, lung injuries are generally more serious and prolonged. From a kinetic perspective, the authors thus assessed whether lung expression of proinflammatory cytokines were altered with age following intratracheal lipopolysaccharide (LPS) challenge in mice. Tumor necrosis factor-alpha, interleukin-1 beta, macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-2, and keratinocyte-derived chemokine were significantly higher in 65-week-old mice along with sustained neutrophilia when compared to 11-week-old mice at 72 hours, but not at earlier time points. The authors concluded that the degree of LPS-induced neutrohilic inflammation and the expression of these cytokines differ with age at later phases of acute lung injury.
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