Journal
CHEMICAL RECORD
Volume 7, Issue 6, Pages 354-361Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/tcr.20135
Keywords
flavin; organocatalyst; aerobic oxidation; aerobic hydrogenation; hydrogen peroxide; Baeyer-Villiger oxidation
Categories
Ask authors/readers for more resources
Recent progress in the development of flavin-catalyzed oxidations and related reactions is described with respect to scope, limitation, and reaction mechanism. The 4a-hydroperoxy-flavins, which are the most simplified model compounds of flavoenzymes, act as catalytically active species for the oxidation of organic substrates with the help of H2O2 or O-2 as a mild oxidant. This principle behind the simulation of flavoenzymes led to the discovery of a variety of environmentally benign, oxidative transformations of secondary amines to nitrones, tertiary amines to N-oxides, Sulfides to sulfoxides, and Baeyer-Villiger oxidations of ketones. Asymmetric oxidation of sulfides can also be performed with several chiral flavin catalysts. One of the fortunate outcomes of this study is the development of an environmentally friendly (green) method for the aerobic hydrogenation of olefins, which is achieved by in situ generation of diimide with the aid of the flavin-catalyzed oxidation of hydrazine under an 0, atmosphere. (C) 2007 The Japan Chemical Journal Forum and Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available