Journal
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Volume 64, Issue 2, Pages 213-221Publisher
SPRINGER
DOI: 10.1007/s00280-009-0991-z
Keywords
Hydroxyurea; Hydroxamic acid derivatives; Cancer
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Funding
- Croatian Ministry of Science, Education and Sport's [098-0982464-2393]
- Foundation of Croatian Academy of Sciences and Arts
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Hydroxyurea has been used for decades and it is still valuable for the treatment of some types of cancer. It inhibits ribonucleotide reductase (RNR) enzyme known to be crucial in the conversion of ribonucleotides into deoxyribonucleotides. However, nowadays the main focus has shifted to structurally similar hydroxamic acid derivatives that target specific enzymes involved in cancer progression such as histone deacetylases, matrix metalloproteinases and also RNR.
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