Journal
STEM CELL REVIEWS
Volume 3, Issue 2, Pages 137-146Publisher
HUMANA PRESS INC
DOI: 10.1007/s12015-007-0024-4
Keywords
niche; stem cells; mammary gland; microenvironment
Categories
Funding
- NCI NIH HHS [R01 CA064786-07, R01 CA064786, CA-57621, R01 CA057621-07, R37 CA064786, R01 CA057621, CA-64786] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA057621, R01CA064786, R37CA064786] Funding Source: NIH RePORTER
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In most adult tissues there reside pools of stem and progenitor cells inside specialized microenvironments referred to as niches. The niche protects the stem cells from inappropriate expansion and directs their critical ftinctions. Thus guided, stem cells are able to maintain tissue homeostasis throughout the ebb and flow of metabolic and physical demands encountered over a lifetime. Indeed, a pool of stem cells maintains mammary gland structure throughout development, and responds to the physiological demands associated with pregnancy. This review discusses how stem cells were identified in both human and mouse mammary glands; each requiring different techniques that were determined by differing biological needs and ethical constraints. These studies together create a robust portrait of mammary gland biology and identify the location of the stem cell niche, elucidate a developmental hierarchy, and suggest how the niche might be manipulated for therapeutic benefit.
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