Journal
JOURNAL OF ENDOTOXIN RESEARCH
Volume 13, Issue 4, Pages 243-247Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0968051907082609
Keywords
bordetella; evolution; lipid A modification; Toll-like receptor 4
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI053075] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI053075-04, R01 AI053075-03, R01 AI053075-02, R01-AI053075-02, R01 AI053075-01A1, R01 AI053075, R01 AI053075-05] Funding Source: Medline
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The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.
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