Journal
CANCER CELL INTERNATIONAL
Volume 13, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1475-2867-13-37
Keywords
MALT1; A20; NF-kappa B; T cells; Acute myeloid leukemia
Categories
Funding
- National Natural Science Foundation of China [91129720, 81270604]
- Fundamental Research Funds for the Central Universities [21612116]
Ask authors/readers for more resources
To elucidate the characteristics of T-cell receptor (TCR) signal transduction in T-cells from acute myeloid leukemia (AML), the mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), A20, NF-kappa B and MALT1-V1 gene expression levels in CD3(+) T cells sorted from the peripheral blood of patients with AML were analyzed by real-time PCR. A significantly lower MALT1 and A20 expression level was found in T cells from patients with AML compared with healthy controls (p = 0.045, p < 0.0001); however, the expression level of MALT1-V1 (variant 1) was significantly higher in the AML group than in the healthy control group (p = 0.006), and the expression level of NF-kappa B was increased in the AML group. In conclusion, the characteristics of the expression pattern of MALT1-A20-NF-kappa B and the distribution of MALT1 variants in T cells from AML were first characterized. Overall, low TCR-CD3 signaling is related to low MALT1 expression, which may related to T cell immunodeficiency, while the up-regulation of MALT1-V1 may play a role in overcoming the T cell activity by downregulating A20 in patients with AML, which may be related to a specific response to AML-associated antigens.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available