Journal
CANCER CELL
Volume 26, Issue 2, Pages 288-300Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2014.06.005
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Funding
- Brain Tumor Center Grants, MSKCC
- NIH [U54CA163167-01, U01CA141502-01, RO1CA100688, U54CA143798]
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To understand the relationships between the non-GCIMP glioblastoma (GBM) subgroups, we performed mathematical modeling to predict the temporal sequence of driver events during tumorigenesis. The most common order of evolutionary events is 1) chromosome (chr) 7 gain and chr10 loss, followed by 2) CDKN2A loss and/or TP53 mutation, and 3) alterations canonical for specific subtypes. We then developed a computational methodology to identify drivers of broad copy number changes, identifying PDGFA (chr7) and PTEN (chr10) as driving initial nondisjunction events. These predictions were validated using mouse modeling, showing that PDGFA is sufficient to induce proneural-like glionrias and that additional NF1 loss converts proneural to the mesenchymal subtype. Our findings suggest that most non-GCIMP mesenchymal GBMs arise as, and evolve from, a proneural-like precursor.
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