Journal
CANCER CELL
Volume 25, Issue 3, Pages 304-317Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2014.01.021
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Funding
- UK, AICR
- Royal Society/Wellcome trust
- MRC [MC_UP_1203/3] Funding Source: UKRI
- Cancer Research UK [18274] Funding Source: researchfish
- Medical Research Council [MC_UP_1203/3] Funding Source: researchfish
- Worldwide Cancer Research [11-0626] Funding Source: researchfish
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Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.
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