Journal
CANCER CELL
Volume 22, Issue 6, Pages 709-724Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2012.10.012
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Funding
- Spanish Ministry of Science and Innovation [BFU2008-01042, SAF2010-21143, CSD2007-00017]
- Spanish Fondo de Investigaciones Sanitarias [FIS PS09/00373]
- CONSOLIDER-INGENIO [CSD2007-00023]
- Generalitat Valenciana [Prometeo 2008/049, ISIC/2012/010]
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The epithelial-mesenchymal transition (EMT) is required in the embryo for the formation of tissues for which cells originate far from their final destination. Carcinoma cells hijack this program for tumor dissemination. The relevance of the EMT in cancer is still debated because it is unclear how these migratory cells colonize distant tissues to form macrometastases. We show that the homeobox factor Prrx1 is an EMT inducer conferring migratory and invasive properties. The loss of Prrx1 is required for cancer cells to metastasize in vivo, which revert to the epithelial phenotype concomitant with the acquisition of stem cell properties. Thus, unlike the classical EMT transcription factors, Prrx1 uncouples EMT and sternness, and is a biomarker associated with patient survival and lack of metastasis.
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