Journal
CANCER CELL
Volume 21, Issue 2, Pages 168-180Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2011.12.023
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Funding
- National Institutes of Health [CA-096832, CA-21765]
- American Brain Tumor Association
- Mochida Foundation
- Anderson fellowship
- American Lebanese Syrian Associated Charities of St. Jude Children's Research Hospital
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Medulloblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called MYC-subgroup differs in its histopathology, gene expression profile, and clinical behavior from other forms of medulloblastoma. We generated a mouse model of MYC-subgroup medulloblastonna by transducing Trp53-null cerebellar progenitor cells with Myc. The cardinal features of these mouse medulloblastomas closely mimic those of human MYC-subgroup tumors and significantly differ from mouse models of the Sonic-Hedgehog- and WNT-disease subgroups. This mouse model should significantly accelerate understanding and treatment of the most aggressive form of medulloblastoma and infers distinct roles for MYC and MYCN in tumorigenesis.
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